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Cefotaxime is usually used for the treatment of a documented or suspected meningitis due to susceptible organisms such as H. influenzae and N.meningitidis, nonpseudomonal gram-negative rod infection. Sodium Bicarbonate is infused to treat metabolic acidosis and to alkalinize urine, to treat life-threating hyperkalemia , to stabilize the acid base status in cardiac arrest. It is generally recognized that sodium bicarbonate , which is stabilized at pH 7.0∼8.5, cannot be mixed with cefotaxime injection solution. So we did study about the stability of cefotaxime when it was mixed with sodium bicarbonate in 5% dextrose solution. The test sample was prepared in D5W infusion solution in which sodium bicarbonate and cefotaxime were mixed 1:1 in four different concentrations. Sample "A" solution was prepared with cefotaxime(1mL, 100mg/mL) and sodium bicarbonate(0.5mL/50mL D5W). Sample "B" was prepared with cefotaxime(1mL, 100mg/mL) and sodium bicarbonate(1mL/50mL D5W). Sample "C" was prepared with cefotaxime(1mL, 100mg/mL) and sodium bicarbonate(2mL/50mL D5W). Sample "D" was prepared with cefotaxime(1mL, 100mg/mL) and sodium bicarbonate(3mL/50mL D5W). The cefotaxime concentrations were determined HPLC methods at 0, 3, 6, 12, 24, 48 hours. Sample "C" was most stable among samples. The concentrations of sample "C" are 99.11%(3hr), 95.94%(6hr), 94.72%(12hr), 92.13%(24hr). So we can infuse cefotaxime injection into the line of sodium bicarbonate diluted in D5W for 24hours at room temperature without significant decay in clinical situations. If we infuse two drugs by Y site, they are contacted for a short time. So we can infuse cefotaxime and bicarbonate in D5W by Y site.
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